Tips for handling being blocked at a major ISP

This depends on the block in question and at what ISP. First is to determine which ISP (Gmail, Yahoo, Microsoft, etc) is blocking your mail. This can be evidenced in the bounce logs, and can be apparent if your delivery rates at a given provider are lower than usual. Once you've identified the impacted provider, you should review your practices to ensure that you’re following best practice recommendations. If you find you are not, remedy the situation by fixing the problem first, then reach out to the ISP to request a delisting and detail all the changes implemented to follow industry best practices.